Expression of androgen receptor and prostate-specific antigen in male breast carcinomaReport as inadecuate




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Breast Cancer Research

, 6:R18

First Online: 07 November 2003Received: 17 March 2003Revised: 02 October 2003Accepted: 09 October 2003

Abstract

BackgroundThe androgen-regulated proteins prostate-specific antigen PSA and prostate-specific acid phosphatase PSAP are present in high concentrations in normal prostate and prostatic cancer and are considered to be tissue-specific to prostate. These markers are commonly used to diagnose metastatic prostate carcinoma at various sites including the male breast. However, expression of these two proteins in tumors arising in tissues regulated by androgens such as male breast carcinoma has not been thoroughly evaluated.

MethodsIn this study we analyzed the expression of PSA, PSAP and androgen receptor AR by immunohistochemistry in 26 cases of male breast carcinomas and correlated these with the expression of other prognostic markers.

ResultsAR, PSA and PSAP expression was observed in 81%, 23% and 0% of carcinomas, respectively. Combined expression of AR and PSA was observed in only four tumors.

ConclusionAlthough the biological significance of PSA expression in male breast carcinomas is not clear, caution should be exercised when it is used as a diagnostic marker of metastatic prostate carcinoma.

Keywordsandrogen receptor immunohistochemistry male breast carcinoma prostate-specific antigen AbbreviationsARandrogen receptor

ERestrogen receptor

FBCfemale breast carcinoma

MBCmale breast carcinoma

PRprogesterone receptor

PSAprostate-specific antigen

PSAPprostate-specific acid phosphatase.

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Author: Noman Kidwai - Yun Gong - Xiaoping Sun - Charuhas G Deshpande - Anjana V Yeldandi - M Sambasiva Rao - Sunil Badve

Source: https://link.springer.com/







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