Multiple roles of TNF super family members in corpus luteum functionReport as inadecuate

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Reproductive Biology and Endocrinology

, 1:95

First Online: 10 November 2003Received: 09 April 2003Accepted: 10 November 2003


The main function of the corpus luteum CL is the production of progesterone. Adequate luteal progesterone is crucial for determining the physiological duration of the estrous cycle and for achieving a successful pregnancy. The CL is regulated not only by hypophyseal gonadotropin, but also by a number of cytokines that are locally produced. Tumor necrosis factor-α TNF and its specific receptors TNFR are present in the CL of many species. TNF plays multiple and likely important roles in CL function throughout the estrous cycle. TNF appears to have luteotropic and luteolytic roles in the CLs. In contrast, Fas ligand Fas L, another member of TNF super family TNF-SF, is primarily recognized for its apoptotic actions. Presumably, Fas L binds its cognate receptor Fas to induce structural luteolysis. This review is designed to focus on recent studies documenting the expression of TNF and Fas L, their receptors, and intracellular signaling mechanisms in the CL.

Electronic supplementary materialThe online version of this article doi:10.1186-1477-7827-1-95 contains supplementary material, which is available to authorized users.

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Author: Kiyoshi Okuda - Ryosuke Sakumoto


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