Regulation of intraluteal production of prostaglandinsReport as inadecuate




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Reproductive Biology and Endocrinology

, 1:91

First Online: 10 November 2003Received: 10 May 2003Accepted: 10 November 2003

Abstract

There is clear evidence for intraluteal production of prostaglandins PGs in numerous species and under a variety of experimental conditions. In general, secretion of PGs appears to be elevated in the early corpus luteum CL and during the period of luteolysis. Regulation of intraluteal PG production is regulated by a variety of factors. An autoamplification pathway in which PGF-2alpha stimulates intraluteal production of PGF-2alpha has been identified in a number of species. The mechanisms underlying this autoamplification pathway appear to differ by species with expression of Cyclooxygenase-2 Cox-2 and activity of phospholipase A2 acting as important physiological control points. In addition, a number of other responses that are induced by PGF-2alpha decreased luteal progesterone, increased endothelin-1, increased cytokines also have been found to increase intraluteal PGF-2alpha production. Thus, regulation of intraluteal PG production may serve to initiate or amplify physiological signals to the CL and may be important in specific aspects of luteal physiology particularly during luteal regression.

Electronic supplementary materialThe online version of this article doi:10.1186-1477-7827-1-91 contains supplementary material, which is available to authorized users.

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Author: Milo C Wiltbank - Joseph S Ottobre

Source: https://link.springer.com/







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