Prevention of mammary carcinogenesis by short-term estrogen and progestin treatmentsReport as inadecuate




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Breast Cancer Research

, 6:R31

First Online: 11 November 2003Received: 08 August 2003Revised: 25 September 2003Accepted: 09 October 2003

Abstract

IntroductionWomen who have undergone a full-term pregnancy before the age of 20 have one-half the risk of developing breast cancer compared with women who have never gone through a full-term pregnancy. This protective effect is observed universally among women of all ethnic groups. Parity in rats and mice also protects them against chemically induced mammary carcinogenesis.

MethodsSeven-week-old virgin Lewis rats were given N-methyl-N-nitrosourea. Two weeks later the rats were treated with natural or synthetic estrogens and progestins for 7–21 days by subcutaneous implantation of silastic capsules.

ResultsIn our current experiment, we demonstrate that short-term sustained exposure to natural or synthetic estrogens along with progestins is effective in preventing mammary carcinogenesis in rats. Treatment with 30 mg estriol plus 30 mg progesterone for 3 weeks significantly reduced the incidence of mammary cancer. Short-term exposure to ethynyl estradiol plus megesterol acetate or norethindrone was effective in decreasing the incidence of mammary cancers. Tamoxifen plus progesterone treatment for 3 weeks was able to confer only a transient protection from mammary carcinogenesis, while 2-methoxy estradiol plus progesterone was effective in conferring protection against mammary cancers.

ConclusionsThe data obtained in the present study demonstrate that, in nulliparous rats, long-term protection against mammary carcinogenesis can be achieved by short-term treatments with natural or synthetic estrogen and progesterone combinations.

Keywordscancer estrogen mammary prevention progestin AbbreviationshCGhuman chorionic gonadotropin

ILinterleukin

MNUN-methyl-N-nitrosourea.

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Author: Lakshmanaswamy Rajkumar - Raphael C Guzman - Jason Yang - Gudmundur Thordarson - Frank Talamantes - Satyabrata Nandi

Source: https://link.springer.com/



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