Model-Based Design and Experimental Validation of Control Modules for Neuromodulation DevicesReport as inadecuate




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1 LTSI - Laboratoire Traitement du Signal et de l-Image 2 CAMIN - Control of Artificial Movement and Intuitive Neuroprosthesis LIRMM - Laboratoire d-Informatique de Robotique et de Microélectronique de Montpellier, CRISAM - Inria Sophia Antipolis - Méditerranée 3 Sorin Group Clamart 4 HEGP - Hôpital Européen Georges Pompidou APHP 5 CIC-IT Rennes 6 Service de cardiologie et maladies vasculaires

Abstract : The goal of this paper is to propose a model-based control design framework, adapted to the development of control modules for medical devices. A particular example is presented in which instantaneous heart rate is regulated in real-time, by modulating, in an adaptive manner, the current delivered to the vagus nerve by a neuromodulator. The proposed framework couples a control module, based on a classical PI controller, a mathematical model of the medical device, and a physiological model representing the cardiovascular responses to vagus nerve stimulation VNS. In order to analyze and evaluate the behavior of the device, different control parameters are tested on a -virtual population,- generated with the model, according to the Latin Hypercube sampling method. In particular, sensitivity analyses are applied for the identification of a domain of interest in the space of the control parameters. The obtained control parameter domain has been validated in an experimental evaluation on six sheep. A range of control parameters leading to accurate results was successfully estimated by the proposed model-based design method. Experimental evaluation of the control parameters inside such a domain led to the best compromise between accuracy and time response of the VNS control. The feasibility and usefulness of the proposed model-based design method were shown, leading to a functional, real-time closed-loop control of the VNS for the regulation of heart rate.

Keywords : Heart rate model-based control design modeling simulation vagus nerve stimulation





Author: Hector M Romero Ugalde - David Ojeda - Virginie Le Rolle - David Andreu - David Guiraud - Jean-L Bonnet - Christine Henry - Nicol

Source: https://hal.archives-ouvertes.fr/



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