Micro-to-Nano Biomechanical Modeling for Assisted Biological Cell InjectionReport as inadecuate




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* Corresponding author 1 SAARA - Simulation, Analyse et Animation pour la Réalité Augmentée LIRIS - Laboratoire d-InfoRmatique en Image et Systèmes d-information 2 DMS PRISME - Laboratoire Pluridisciplinaire de Recherche en Ingénierie des Systèmes, Mécanique et Energétique 3 Pôle IRAUS PRISME - Laboratoire Pluridisciplinaire de Recherche en Ingénierie des Systèmes, Mécanique et Energétique

Abstract : To facilitate training of biological cell injection operations, we are developing an interactive virtual environment to simulate needle insertion into biological cells. This paper presents methodologies for dynamic modeling, visual-haptic display and model validation of cell injection. We first investigate the challenging issues in the modeling of the biomechanical properties of living cells. We propose two dynamic models to simulate cell deformation and puncture. The first approach is based on the assumptions that the mechanical response of living cells is mainly determined by the cytoskeleton and that the cytoskeleton is organized as a tensegrity structure including microfilaments, microtubules and intermediate filaments. Equivalent microtubules struts are represented with a linear mass-tensor finite element model and equivalent microfilaments and intermediate filaments with viscoelastic Kelvin-Voigt elements. The second modeling method assumes the overall cell as an homogeneous hyperelastic model St-Venant-Kirchhoff. Both graphic and haptic rendering are provided in real-time to the operator through a 3D virtual environment. Simulated responses are compared to experimental data to show the effectiveness of the proposed physically-based model.

Keywords : Biomechanics cell injection finite element modeling haptic interaction





Author: Hamid Ladjal - Jean-Luc Hanus - Antoine Ferreira -

Source: https://hal.archives-ouvertes.fr/



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