Th2 cytokines and asthma — Interleukin-9 as a therapeutic target for asthmaReport as inadecuate




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Respiratory Research

, 2:80

First Online: 15 February 2001Received: 13 December 2000Accepted: 08 January 2001

Abstract

Asthma is a complex heritable inflammatory disorder of the airways in which the development of clinical disease depends on environmental exposure. It has been well established that T helper type 2 TH2 lymphocytes and their cytokines have an important role in allergic asthma. Interleukin IL-9, a member of the TH2 cytokine family, has recently been implicated as an essential factor in determining mucosal immunity and susceptibility to atopic asthma. In this review we examine the critical experiments and observations that support this hypothesis. We also discuss these results in comparison with the experiments supporting the involvement of other TH2 cytokines such as IL-4, IL-5 and IL-13.

Keywordsasthma genetics interleukin-9 target transgenic AbbreviationsAHRairway hyperresponsiveness

BALbronchoalveolar lavage

ILinterleukin

rIL-9recombinant mouse IL-9

TH2T helper type 2.

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Author: Yuhong Zhou - Michael McLane - Roy C Levitt

Source: https://link.springer.com/



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