Anorexigen-induced pulmonary hypertension and the serotonin 5-HT hypothesis: lessons for the future in pathogenesisReport as inadecuate




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Respiratory Research

, 3:9

First Online: 20 November 2001Received: 25 June 2001Revised: 28 August 2001Accepted: 07 September 2001

Abstract

Epidemiological studies have established that fenfluramine, D-fenfluramine, and aminorex, but not other appetite suppressants, increase the risk of primary pulmonary hypertension PH. One current hypothesis suggests that fenfluramine-like medications may act through interactions with the serotonin 5-hydroxytryptamine 5-HT transporter 5-HTT located on pulmonary artery smooth muscle cells and responsible for the mitogenic action of 5-HT. Anorexigens may contribute to PH by boosting 5-HT levels in the bloodstream, directly stimulating smooth muscle cell growth, or altering 5-HTT expression. We suggest that individuals with a high basal level of 5-HTT expression related to the presence of the long 5-HTT gene promoter variant may be particularly susceptible to one or more of these potential mechanisms of appetite-suppressant-related PH.

Keywordsanorexigens appetite suppressants pulmonary hypertension pulmonary vascular smooth muscle cells serotonin transporter Abbreviations5-HT5-hydroxytryptamine

5-HTT5-hydroxytryptamine transporter

PHpulmonary hypertension

SMCsmooth muscle cell.

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Author: Saadia Eddahibi - Serge Adnot

Source: https://link.springer.com/







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