Comparative efficacy of two microdoses of a potentized homoeopathic drug, Cadmium Sulphoricum, in reducing genotoxic effects produced by cadmium chloride in mice: a time course studyReport as inadecuate




Comparative efficacy of two microdoses of a potentized homoeopathic drug, Cadmium Sulphoricum, in reducing genotoxic effects produced by cadmium chloride in mice: a time course study - Download this document for free, or read online. Document in PDF available to download.

BMC Complementary and Alternative Medicine

, 1:9

First Online: 23 November 2001Received: 02 August 2001Accepted: 23 November 2001

Abstract

BackgroundCadmium poisoning in the environment has assumed an alarming problem in recent years. Effective antimutagenic agents which can reverse or combat cadmium induced genotoxicity in mice have not yet been reported. Therefore, in the present study, following the homeopathic principle of -like cures like-, we tested the efficacy of two potencies of a homeopathic drug, Cadmium Sulphoricum Cad Sulph, in reducing the genotoxic effects of Cadmium chloride in mice.

Another objective was to determine the relative efficacy of three administrative modes, i.e. pre-, post- and combined pre and post-feeding of the homeopathic drugs. For this, healthy mice, Mus musculus, were intraperitoneally injected with 0.008% solution of CdCl2 @ 1 ml-100 gm of body wt i.e. 0.8 mcg-gm of bw, and assessed for the genotoxic effects through such studies as chromosome aberrations CA, micronucleated erythrocytes MNE, mitotic index MI and sperm head anomaly SHA, keeping suitable succussed alcohol fed positive and CdCl2 untreated normal negative controls. The CdCl2 treated mice were divided into 3 subgroups, which were orally administered with the drug prior to, after and both prior to and after injection of CdCl2 at specific fixation intervals and their genotoxic effects were analyzed.

ResultsWhile the CA, MNE and SHA were reduced in the drug fed series as compared to their respective controls, the MI showed an apparent increase. The combined pre- and post-feeding of Cad Sulph showed maximum reduction of the genotoxic effects.

ConclusionsBoth Cad Sulph-30 and 200 were able to combat cadmium induced genotoxic effects in mice and that combined pre- and post-feeding mode of administration was found to be most effective in reducing the genotoxic effect of CdCl2 followed by the post-feeding mode.

Electronic supplementary materialThe online version of this article doi:10.1186-1472-6882-1-9 contains supplementary material, which is available to authorized users.

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Author: Swapna S Datta - Palash P Mallick - Anisur AR Rahman Khuda-Bukhsh

Source: https://link.springer.com/



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