Pharmacogenetics, pharmacogenomics and airway diseaseReport as inadecuate




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Respiratory Research

, 3:10

First Online: 26 November 2001Received: 08 May 2001Revised: 23 October 2001Accepted: 23 October 2001

Abstract

The availability of a draft sequence for the human genome will revolutionise research into airway disease. This review deals with two of the most important areas impinging on the treatment of patients: pharmacogenetics and pharmacogenomics. Considerable inter-individual variation exists at the DNA level in targets for medication, and variability in response to treatment may, in part, be determined by this genetic variation. Increased knowledge about the human genome might also permit the identification of novel therapeutic targets by expression profiling at the RNA genomics or protein proteomics level. This review describes recent advances in pharmacogenetics and pharmacogenomics with regard to airway disease.

Keywordsasthma chronic obstructive pulmonary disease expression profiling pharmacogenetics pharmacogenomics proteomics single-nucleotide polymorphism AbbreviationsIL-4interleukin-4

SNPsingle-nucleotide polymorphism.

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Author: Ian P Hall

Source: https://link.springer.com/



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