First Siena International Conference on Animal Models of Chronic Obstructive Pulmonary Disease, Certosa di Pontignano, University of Siena, Italy, September 30-October 2, 2001Report as inadecuate




First Siena International Conference on Animal Models of Chronic Obstructive Pulmonary Disease, Certosa di Pontignano, University of Siena, Italy, September 30-October 2, 2001 - Download this document for free, or read online. Document in PDF available to download.

Respiratory Research

, 3:12

First Online: 28 November 2001Received: 09 October 2001Accepted: 25 October 2001

Abstract

The meeting proved of great interest to those developing an animal model of chronic obstructive pulmonary disease COPD. COPD is caused by cigarette smoking, evidenced by deterioration in lung function. Lung function is only rarely assessed in animal models. A cigarette smoke driven pathology should provide the best in vivo model for COPD. However, as lesions produced this way take 8–12 months to develop other strategies have to be employed. Emphysematous lesions were also achieved by treatment with elastase, lipopolysaccharide, ozone and other inducers. Several studies described treatments that have shown activity in these models. Transgenic models were discussed, as was the importance of species and strain selection.

Keywordsanimal models COPD cigarette smoke elastase lung function AbbreviationsCOPDchronic obstructive pulmonary disease.

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Author: David Hele

Source: https://link.springer.com/



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