Surfactant gene polymorphisms and interstitial lung diseasesReport as inadecuate




Surfactant gene polymorphisms and interstitial lung diseases - Download this document for free, or read online. Document in PDF available to download.

Respiratory Research

, 3:14

First Online: 29 November 2001Received: 20 July 2001Revised: 17 August 2001Accepted: 31 August 2001

Abstract

Pulmonary surfactant is a complex mixture of phospholipids and proteins, which is present in the alveolar lining fluid and is essential for normal lung function. Alterations in surfactant composition have been reported in several interstitial lung diseases ILDs. Furthermore, a mutation in the surfactant protein C gene that results in complete absence of the protein has been shown to be associated with familial ILD. The role of surfactant in lung disease is therefore drawing increasing attention following the elucidation of the genetic basis underlying its surface expression and the proof of surfactant abnormalities in ILD.

Keywordsgenetics interstitial lung disease polymorphism surfactant Abbreviationsaaamino acid

BALbronchoalveolar lavage

IPFidiopathic pulmonary fibrosis

ILDinterstitial lung disease

SNPsingle nucleotide polymorphism

SPsurfactant protein.

Download fulltext PDF



Author: Panagiotis Pantelidis - Srihari Veeraraghavan - Roland M du Bois

Source: https://link.springer.com/







Related documents