Investigation of glutathione S-transferase zeta and the development of sporadic breast cancerReport as inadecuate




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Breast Cancer Research

, 3:409

First Online: 01 December 2001Received: 29 May 2001Revised: 03 September 2001Accepted: 05 September 2001

Abstract

BackgroundCertain genes from the glutathione S-transferase superfamily have been associated with several cancer types. It was the objective of this study to determine whether alleles of the glutathione S-transferase zeta 1 GSTZ1 gene are associated with the development of sporadic breast cancer.

MethodsDNA samples obtained from a Caucasian population affected by breast cancer and a control population, matched for age and ethnicity, were genotyped for a polymorphism of the GSTZ1 gene. After PCR, alleles were identified by restriction enzyme digestion and results analysed by chi-square and CLUMP analysis.

ResultsChi-squared analysis gave a χ value of 4.77 three degrees of freedom with P = 0.19, and CLUMP analysis gave a T1 value of 9.02 with P = 0.45 for genotype frequencies and a T1 value of 4.77 with P = 0.19 for allele frequencies.

ConclusionStatistical analysis indicates that there is no association of the GSTZ1 variant and hence the gene does not appear to play a significant role in the development of sporadic breast cancer.

Keywordsglutathione S-transferase zeta GSTZ1 sporadic breast cancer Abbreviationsbpbase pairs

GSTglutathione S-transferase

GSTZ1glutathione S-transferase zeta 1

PCRpolymerase chain reaction.

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Author: Robert A Smith - Joanne E Curran - Stephen R Weinstein - Lyn R Griffiths

Source: https://link.springer.com/



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