C-reactive protein levels in patients at cardiovascular risk: EURIKA studyReport as inadecuate




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* Corresponding author 1 Wales Heart Research Institute 2 Swansea University College of Medicine 3 CIC epidémiologie clinique- essais cliniques, Hôpital Bichat - Claude Bernard 4 UPD7 - Université Paris Diderot - Paris 7 5 Department of Preventive Medicine and Public Health 6 Centros de Investigación Biomédica en Red CIBER 7 Epidémiologie des maladies chroniques : impact des interactions gène environnement sur la santé des populations 8 Department of Public Health 9 Departments of Epidemiology and Medicine and Welch Center of Prevention, Epidemiology and Clinical Research 10 Department of Cardiovascular Epidemiology and Population Genetics 11 AstraZeneca Global Medical Affairs 12 Medical Evidence Centre 13 School of Health and Caring Sciences 14 Hôpital Bichat - Claude Bernard 15 LVTS - Laboratoire de Recherche Vasculaire Translationnelle 16 Department of Internal Medicine, Ageing and Clinical Nephrology

Abstract : BackgroundElevated C-reactive protein CRP levels are associated with high cardiovascular risk, and might identify patients who could benefit from more carefully adapted risk factor management. We have assessed the prevalence of elevated CRP levels in patients with one or more traditional cardiovascular risk factors.MethodsData were analysed from the European Study on Cardiovascular Risk Prevention and Management in Usual Daily Practice EURIKA, ClinicalTrials.gov Identifier: NCT00882336, which included patients aged ≥50 years from 12 European countries with at least one traditional cardiovascular risk factor but no history of cardiovascular disease. Analysis was also carried out on the subset of patients without diabetes mellitus who were not receiving statin therapy.ResultsIn the overall population, CRP levels were positively correlated with body mass index and glycated haemoglobin levels, and were negatively correlated with high-density lipoprotein cholesterol levels. CRP levels were also higher in women, those at higher traditionally estimated cardiovascular risk and those with greater numbers of metabolic syndrome markers. Among patients without diabetes mellitus who were not receiving statin therapy, approximately 30% had CRP levels ≥3 mg-L, and approximately 50% had CRP levels ≥2 mg-L, including those at intermediate levels of traditionally estimated cardiovascular risk.ConclusionsCRP levels are elevated in a large proportion of patients with at least one cardiovascular risk factor, without diabetes mellitus who are not receiving statin therapy, suggesting a higher level of cardiovascular risk than predicted according to conventional risk estimation systems.Trial registrationClinicalTrials.gov Identifier: NCT00882336

Keywords : C-reactive protein Cardiovascular disease Epidemiology Risk factors-global assessment





Author: Julian Halcox - Carine Roy - Florence Tubach - José Banegas - Jean Dallongeville - Guy De Backer - Eliseo Guallar - Ogün Sazova

Source: https://hal.archives-ouvertes.fr/



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