Effect of leucovorin folinic acid on the developmental quotient of children with Downs syndrome trisomy 21 and influence of thyroid status.Report as inadecuate




Effect of leucovorin folinic acid on the developmental quotient of children with Downs syndrome trisomy 21 and influence of thyroid status. - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 Institut Jérôme Lejeune 2 LMA2 - Laboratoire de Mathématiques Appliquées Agrocampus 3 Académie nationale de médecine 4 Service de Biochimie et Génétique Moléculaire CHU Limoges 5 EA4021 - Biomolécules Thérapies anti-tumorales

Abstract : BACKGROUND: Seven genes involved in folate metabolism are located on chromosome 21. Previous studies have shown that folate deficiency may contribute to mental retardation in Down-s syndrome DS. METHODOLOGY: We investigated the effect of oral folate supplementation daily dose of 1.0+-0.3 mg-kg on cognitive functions in DS children, aged from 3 to 30 months. They received 1 mg-kg leucovorin or placebo daily, for 12 months, in a single-centre, randomised, double-blind study. Folinic acid leucovorin, LV was preferred to folic acid as its bioavailability is higher. The developmental age DA of the patients was assessed on the Brunet-Lezine scale, from baseline to the end of treatment. RESULTS: The intent-to-treat analysis 113 patients did not show a positive effect of leucovorin treatment. However, it identified important factors influencing treatment effect, such as age, sex, and concomitant treatments, including thyroid treatment in particular. A per protocol analysis was carried out on patients evaluated by the same examiner at the beginning and end of the treatment period. This analysis of 87 patients 43 LV-treated vs. 44 patients on placebo revealed a positive effect of leucovorin on developmental age DA. DA was 53.1% the normal value with leucovorin and only 44.1% with placebo p



Author: Henri Blehaut - Clotilde Mircher - Aimé Ravel - Martine Conte - Véronique De Portzamparc - Gwendael Poret - Françoise Huon De

Source: https://hal.archives-ouvertes.fr/



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