Plasmacytoid dendritic cells capture and cross-present viral antigens from influenza-virus exposed cells.Report as inadecuate




Plasmacytoid dendritic cells capture and cross-present viral antigens from influenza-virus exposed cells. - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 Institut d-oncologie-développement Albert Bonniot de Grenoble 2 INSERM U823, équipe 9 Immunobiologie et Immunothérapie des Cancers Institut d-oncologie-développement Albert Bonniot de Grenoble

Abstract : Among the different subsets of dendritic cells DC, plasmacytoid dendritic cells PDC play a unique role in secreting large amounts of type I interferons upon viral stimulation, but their efficiency as antigen-presenting cells has not been completely characterized. We show here, by flow cytometry, with human primary blood PDC and with a PDC cell line, that PDC display poor endocytic capacity for soluble or cellular antigens when compared to monocyte-derived myeloid DC. However, immature PDC efficiently take up cellular material from live influenza-exposed cells, subsequently mature and cross-present viral antigens very efficiently to specific CD8+ T cells. Therefore, during viral infection PDC not only secrete immunomodulatory cytokines, but also recognize infected cells and function as antigen cross-presenting cells to trigger the anti-viral immune response.

keyword : plasmacytoid dendritic cells cross-presentation influenza virus





Author: Gabrielle Lui - Olivier Manches - Juliette Angel - Jean-Paul Molens - Laurence Chaperot - Joël Plumas -

Source: https://hal.archives-ouvertes.fr/



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