Pre-vaccination Prevalence and Genotype Distribution of Human Papillomavirus Infection among Women from Urban Tunis: a Cross-sectional Study.Report as inadecuate




Pre-vaccination Prevalence and Genotype Distribution of Human Papillomavirus Infection among Women from Urban Tunis: a Cross-sectional Study. - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 Institut Pasteur de Tunis 2 Department of Gynecology 3 Department of Gynecology Centre de maternité et de Néonatologie Tunis 4 Department of Epidemiology, Observatoire National de Tunis 5 Family Planning Clinic of Ariana Tunis, Tunisia 6 Laboratoire d’Anatomie Pathologique Humaine et Expérimentale

Abstract : To estimate the pre-vaccination distribution of human papillomavirus HPV types amongwomen from urban Tunis. Materials and Methods: A total of 611 women aged 18-69 years were enrolled inthree local gynaecological outpatient departments. All underwent a gynaecological examination with Pap testand dry swab for HPV detection and typing performed by linear array genotyping test Roche. Cytologicalexamination was conducted on conventional Pap smears. Results: HPV DNA was found in 6.5% of the women;the most frequent HPV types were HPV 16 and HPV 11 at 3.27% and 1.96%, respectively. The second mostfrequent high risk HR HPV type was HPV 58 0.82% followed by HPV 18, HPV 31 and HPV 33 found inonly 0.33% of women. Single infections with HPV types, targeted by the quadrivalent vaccine 6, 11, 16, and18, were detected in 3.6 % of the study patients 55% of positive women. HPV infection was found in 3.83% ofwomen with normal cytology and in 47.4% of women with cytological abnormalities. No statistically significanttrend in prevalence by age group emerged for any HPV type or for high or low risk types. Conclusions: Thesedata show a relatively low prevalence of HPV infection in women from urban Tunis with a high proportion ofHPV16 and HPV58. This should be considered in the upcoming screening programs and vaccination strategy.

Keywords : vaccination strategy Human papillomavirus pap smears urban Tunis





Author: Haifa Guettiti - Emma Ennaifer - Leila Attia - Dalenda Chelly - Nissaf Ben Alaya - Rim Ben Aissa - Thalja Laassili - Samir Boubak

Source: https://hal.archives-ouvertes.fr/



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