Contribution of rare and common genetic variants to plasma lipid levels and carotid stiffness and geometry – a substudy of the Paris Prospective Study 3 Short title: Genetic variants and carotid stiffnessReport as inadecuate




Contribution of rare and common genetic variants to plasma lipid levels and carotid stiffness and geometry – a substudy of the Paris Prospective Study 3 Short title: Genetic variants and carotid stiffness - Download this document for free, or read online. Document in PDF available to download.

1 ICAN - Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition 2 PARCC - Paris-Centre de Recherche Cardiovasculaire 3 DALEMBERT - Institut Jean Le Rond d-Alembert 4 HEGP - Hôpital Européen Georges Pompidou APHP 5 B2A - Adaptation Biologique et Vieillissement = Biological Adaptation and Ageing 6 CIPC - Centre d-Investigations Préventives et Cliniques 7 DCAC - Défaillance Cardiovasculaire Aigüe et Chronique

Abstract : Background: We assess the contribution of common and rare putatively functional genetic variants most of them coding present on the Illumina exome Beadchip to the variability of plasma lipids and stiffness of the common carotid artery. Methods and results: Measurements were obtained from 2283 men and 1398 women, and after filtering and exclusion of monomorphic variants, 32827 common minor allele frequency >0.01 and 68770 rare variants were analyzed. A large fraction of the heritability of plasma lipids is attributable to variants present on the array, especially for Triglycerides fraction of variance attributable to measured genotypes: VG-Vp=31.4%, P



Author: Carole Proust - Jean-Philippe Empana - Pierre Boutouyrie - Maureen Alivon - Pascal Challande - Nicolas Danchin - Guillaume Escrio

Source: https://hal.archives-ouvertes.fr/



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