Intramyocardial protein therapy with vascular endothelial growth factor VEGF-165 induces functional angiogenesis in rat senescent myocardium.Report as inadecuate




Intramyocardial protein therapy with vascular endothelial growth factor VEGF-165 induces functional angiogenesis in rat senescent myocardium. - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 CRRET - Laboratoire de recherche sur la croissance cellulaire, la réparation et la régénération tissulaires 2 PRETA TIMC-IMAG - Techniques de l-Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications Grenoble 3 Radiopharmaceutiques biocliniques

Abstract : Myocardial capillary density and angiogenesis are impaired during aging but whether growth factor therapy is able to induce functional neovascularization in senescent heart have never been studied. In 3, 24, 28 and 32 mo male Wistar rats, cardiac hemodynamic measurements indicated heart failure at 28 and 32 mo, associated with left ventricular hypertrophy. VEGF-VEGF-R2, Ang-1-Ang-2-Tie-2 and PTN levels, quantitated in left ventricle by western blotting and immunohistochemistry, showed that VEGF and VEGF-R2 levels were specifically decreased during aging. In vitro angiogenesis ± rhVEGF-165 5 and 50 ng-mL was measured in aortic segments in 3D-collagen. Aortic sprouting was decreased during aging but restored by VEGF treatment P



Author: Sophie Besse - François Boucher - Gilberte Linguet - Laurent Riou - Joël De Leiris - Bertrand Riou - Julien Dimastromatteo - Re

Source: https://hal.archives-ouvertes.fr/



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