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* Corresponding author 1 Institut Cochin 2 LBFA - Laboratoire de bioénergétique fondamentale et appliquée

Abstract : AMP-activated protein kinase AMPK functions as a signaling hub to balance energy supply with demand. Phosphorylation of activation loop Thr172 has been considered as an essential step in AMPK activation. In this issue of Chemistry & Biology, Scott and colleagues show that the small molecule direct AMPK activator, A-769662, bypasses this phosphorylation event, and acts synergistically with AMP on naive AMPK.

Keywords : AMPK

Author: Benoit Viollet - Marc Foretz - Uwe Schlattner -



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