Bypassing AMPK PhosphorylationReport as inadecuate




Bypassing AMPK Phosphorylation - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 Institut Cochin 2 LBFA - Laboratoire de bioénergétique fondamentale et appliquée

Abstract : AMP-activated protein kinase AMPK functions as a signaling hub to balance energy supply with demand. Phosphorylation of activation loop Thr172 has been considered as an essential step in AMPK activation. In this issue of Chemistry & Biology, Scott and colleagues show that the small molecule direct AMPK activator, A-769662, bypasses this phosphorylation event, and acts synergistically with AMP on naive AMPK.

Keywords : AMPK





Author: Benoit Viollet - Marc Foretz - Uwe Schlattner -

Source: https://hal.archives-ouvertes.fr/



DOWNLOAD PDF




Related documents