Physically based 3D finite element model of single mineralized collagen microfibrilReport as inadecuate




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1 F2ME PRISME - Laboratoire Pluridisciplinaire de Recherche en Ingénierie des Systèmes, Mécanique et Energétique

Abstract : Mineralized collagen microfibrils in human bone provide its mechanical properties stiffness, elasticity, ductility, energy dissipation and strength. However, detailed 3D finite element models describing the mechanical behaviour of the mineralized collagen microfibrils are still lacking. In the current work, we developed a 3D finite element model of the mineralized collagen microfibril that incorporates the physical 3D structural details. The model components consist of five tropocollagen molecules, mineral hydroxyapatite and intermolecular cross-links joining primarily the ends of the tropocollagen molecules. Dimension, arrangement and mechanical behaviour of the constituents are based on previously published experimental and theoretical data. Tensile load was applied to the microfibril under different conditions hydrated and dehydrated collagen to investigate the relationship between the structure and the mechanical behaviour of the mineralized collagen microfibril stress-strain curve and elastic modulus. The computational results match the experimental available data well, and provide insight into the role of the phases and morphology on the microfibril behaviour. Our predicted results show that the mechanical properties of collagen microfibrils arise due to their structure and properties. The proposed 3D finite element model of mineralized collagen microfibril contributes toward the investigation of the bottom-up structure-property relationships in human bone.

Keywords : Bone Mineralized collagen microfibril Cross-links 3D Finite element Structure-property relationship





Author: Ridha Hambli - Abdelwahed Barkaoui -

Source: https://hal.archives-ouvertes.fr/



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