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Abstract: Since the first experimental evidences of active conductances in dendrites,most neurons have been shown to exhibit dendritic excitability through theexpression of a variety of voltage-gated ion channels. However, despiteexperimental and theoretical efforts undertaken in the last decades, the roleof this excitability for some kind of dendritic computation has remainedelusive. Here we show that, owing to very general properties of excitablemedia, the average output of a model of active dendritic trees is a highlynon-linear function of their afferent rate, attaining extremely large dynamicranges above 50 dB. Moreover, the model yields double-sigmoid responsefunctions as experimentally observed in retinal ganglion cells. We claim thatenhancement of dynamic range is the primary functional role of active dendriticconductances. We predict that neurons with larger dendritic trees should havelarger dynamic range and that blocking of active conductances should lead to adecrease of dynamic range.



Author: Leonardo L. Gollo, Osame Kinouchi, Mauro Copelli

Source: https://arxiv.org/







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