Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesityReport as inadecuate




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* Corresponding author 1 Department of animal science 2 Department of internal medicine and specialties 3 Laboratory for molecular medicine and metabolism 4 National Obesity Center Yaoundé 5 Department of medicine 6 Medical diagnostic center, Yaoundé 7 Department of hormaonal biology 8 Department of diabetes and endocrinology 9 Department of animal science 10 CRC - Centre de Recherche des Cordeliers

Abstract : Background : Osteoprotegerin OPG, a soluble member of the tumor necrosis factor receptor superfamily that inhibits bone resorption, has been suggested as a potential marker of cardiovascular risk. This study aimed to assess the relationship between insulin resistance, lipid profile and OPG levels in obese and non-obese sub-Saharan African women.Methods :Sixty obese 44 and non-obese 16 volunteer women aged 18 to 40 years were recruited in this cross-sectional study. Their clinical age, height, weight, waist circumference, systolic and diastolic blood pressures and biochemical parameters fasting blood glucose, total cholesterol, high density lipoprotein-cholesterol HDL-C were measured using standard methods. Insulin levels were measured using an electrochemiluminescence immunoassay, while OPG levels were measured using the ELISA technique. Low density lipoprotein-cholesterol LDL-C, body mass index BMI and Homeostasis Model Assessment of Insulin Resistance HOMA-IR were calculated using standard methods. Abdominal obesity was defined as a waist circumference ≥ 80 cm.Results : OPG levels were higher in obese than in normal subjects, though the difference was not significant p = 0.9. BMI, waist circumference, percent body fat and systolic blood pressure were significantly higher in obese than in non-obese subjects p 



Author: Clarisse Noël Ayina Ayina - Eugene Sobngwi - Mickael Essouma - Jean Jacques N. Noubiap - Philippe Boudou - Laurent Serge Etoundi

Source: https://hal.archives-ouvertes.fr/



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