Advanced Epithelioid Malignant Peripheral Nerve Sheath Tumor Showing Complete Response to Combined Surgery and Chemotherapy: A Case ReportReport as inadecuate




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Case Reports in Oncological MedicineVolume 2011 2011, Article ID 705345, 5 pages

Case Report

Department of Plastic and Reconstructive Surgery, Asahikawa-Kosei General Hospital, 1 Jo-dohri 24-chome 111, Asahikawa City, Hokkaido 078-8211, Japan

Department of Plastic and Reconstructive Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060-0815, Japan

Received 23 May 2011; Accepted 6 July 2011

Academic Editor: G. Di Vagno

Copyright © 2011 Tomohiro Minagawa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Malignant peripheral nerve sheath tumor MPNST is a rare high-grade soft tissue sarcoma. The epithelioid variant accounts for 5% or less of MPNSTs; the clinical behavior of this variant is unclear. Reports of approximately 40 cases are available in the English literature; however, most reports addressed clinicopathological features rather than therapeutic procedures or clinical courses. We describe a case of a 62-year-old male with an epithelioid MPNST of the left foot. Multiple lung metastases developed after radical surgery on the primary lesion. The response to adjuvant chemotherapy including doxorubicin and ifosfamide was favorable, and thoracoscopic resection was subsequently performed on the remaining three metastases. No evidence of recurrence or metastasis was observed at the 12-month followup after the first operation. Further followup and chemotherapy may be required.





Author: Tomohiro Minagawa, Ryuta Shioya, Chigusa Sato, Ryuji Shichinohe, Go Yasui, Kohsuke Ishikawa, and Hiroko Takahashi

Source: https://www.hindawi.com/



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