Gadolinium-based nanoparticles for theranostic MRI-radiosensitizationReport as inadecuate

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1 ILM - Institut Lumière Matière Villeurbanne 2 RMSB - Résonance magnétique des systèmes biologiques 3 UTINAM - Univers, Transport, Interfaces, Nanostructures, Atmosphère et environnement, Molécules

Abstract : A rapid development of gadolinium-based nanoparticles is observed due to their attractive properties as MRI-positive contrast agents. Indeed, they display high relaxivity, adapted biodistribution and passive uptake in the tumor thanks to enhanced permeability and retention effect. In addition to these imaging properties, it has been recently shown that they can act as effective radiosensitizers under different types of irradiation radiotherapy, neutron therapy or hadron therapy. These new therapeutic modalities pave the way to therapy guided by imaging and to personalized medicine.

Keywords : radiotherapy oncology gadolinium MRI multimodality nanoparticles theranostic

Author: François Lux - Lucie Sancey - Andrea Bianchi - Yannick Crémillieux - Stéphane Roux - Olivier Tillement -



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