Spatial navigation impairment in mice lacking cerebellar LTD: a motor adaptation deficitReport as inadecuate




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* Corresponding author 1 LPPA - Laboratoire de physiologie de la perception et de l-action 2 NPA - Neurobiologie des processus adaptatifs 3 Regulation of sensorimotor integration in mouse mutants

Abstract : L7-PKCI transgenic mice, which lack parallel fiber-Purkinje cell long-term depression LTD, were tested with two different mazes to dissociate the relative importance of declarative and procedural components of spatial navigation. We show that L7-PKCI mice are deficient in acquisition of an adapted goal-oriented behavior, part of the procedural component of the task. This supports the hypothesis that cerebellar LTD may subserve a general sensorimotor adaptation process shared by motor and spatial learning functions.





Author: Eric Burguiere - Angelo Arleo - Mohammad Reza Hojjati - Ype Elgersma - Chris I De Zeeuw - Alain Berthoz - Laure Rondi-Reig -

Source: https://hal.archives-ouvertes.fr/



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