Monocyte Chemoattractant Protein-1 2518 A-G Single Nucleotide Polymorphism Might Be Associated with Renal Disease and Thrombocytopenia of SLEReport as inadecuate




Monocyte Chemoattractant Protein-1 2518 A-G Single Nucleotide Polymorphism Might Be Associated with Renal Disease and Thrombocytopenia of SLE - Download this document for free, or read online. Document in PDF available to download.

Journal of Biomedicine and BiotechnologyVolume 2010 2010, Article ID 130265, 6 pages

Research Article

Department of Biochemistry and Molecular Biology, Poznań University of Medical Sciences, 6 Święcickiego St, 60-781 Poznań, Poland

Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

Institute of Rheumatology, Warsaw, Poland

Department of Radiotherapy and Gynecological Oncology, Greater Poland Cancer Centre, 15 Garbary St., 61-866 Poznan, Poland

Received 30 November 2009; Revised 13 February 2010; Accepted 14 March 2010

Academic Editor: Timothy B. Niewold

Copyright © 2010 Piotr Piotrowski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

There is conflicting evidence on the contribution of the MCP-1 −2518 A>G rs 1024611 polymorphism to SLE incidence and clinical manifestations. We examined the prevalence of the MCP-1 −2518 A>G polymorphism in SLE patients and controls in Poland. We did not observe a significant difference in the distribution of MCP-1 −2518 A>G polymorphic variants in patients with SLE and healthy individuals. However, we found an association between the GG versus AG and AA genotypes as well as the AG and GG versus AA genotypes with renal manifestations of SLE 1.123–11.631, and 1.301–4.057, , respectively. We also observed that the MCP-1 AG and GG -genotypes contribute to the occurrence of thrombocytopenia in SLE patients 1.280–5.352, . Our observations indicate that either MCP-1 −2518 G variant can be associated with some clinical findings in patients with SLE.





Author: Piotr Piotrowski, Margarita Lianeri, Robert Gasik, Andrzej Roszak, Marzena Olesińska, and Paweł P. Jagodziński

Source: https://www.hindawi.com/



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