Health behaviors from early to late midlife as predictors of cognitive function: The Whitehall II study.Report as inadecuate

Health behaviors from early to late midlife as predictors of cognitive function: The Whitehall II study. - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé 2 Department of Epidemiology and Public Health 3 Centre de Gérontologie

Abstract : The authors examined associations of health behaviors over a 17-year period, separately and in combination, with cognition in late midlife in 5,123 men and women from the Whitehall II study United Kingdom. Health behaviors were assessed in early midlife mean age = 44 years; phase 1, 1985-1988, in midlife mean age = 56 years; phase 5, 1997-1999, and in late midlife mean age = 61 years; phase 7, 2002-2004. A score of the number of unhealthy behaviors smoking, alcohol abstinence, low physical activity, and low fruit and vegetable consumption was defined as ranging from 0 to 4. Poor defined as scores in the worst sex-specific quintile executive function and memory in late midlife phase 7 were analyzed as outcomes. Compared with those with no unhealthy behaviors, those with 3-4 unhealthy behaviors at phase 1 odds ratio OR = 1.84, 95% confidence interval CI: 1.27, 2.65, phase 5 OR = 2.38, 95% CI: 1.76, 3.22, and phase 7 OR = 2.76, 95% CI: 2.04, 3.73 were more likely to have poor executive function. A similar association was observed for memory. The odds of poor executive function and memory were the greater the more times the participant reported unhealthy behaviors over the 3 phases. This study suggests that both the number of unhealthy behaviors and their duration are associated with subsequent cognitive function in later life.

Keywords : middle aged. cognition health behaviors longitudinal studies middle aged

Author: Séverine Sabia - Hermann Nabi - Mika Kivimaki - Martin Shipley - Michael Marmot - Archana Singh-Manoux -



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