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Journal of Immunology Research - Volume 2014 2014, Article ID 657625, 10 pages -

Review Article

Department of Biochemistry, University Clinic of Navarra, Pamplona, Spain

Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy

Neuroradiology Unit, Sant’Anna Hospital, Ferrara, Italy

Received 6 December 2013; Accepted 3 March 2014; Published 9 April 2014

Academic Editor: Fabio Morandi

Copyright © 2014 Estibaliz Alegre et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Human leukocyte antigen-G HLA-G is a low polymorphic nonclassical HLA-I molecule restrictively expressed and with suppressive functions. HLA-G gene products are quite complex, with seven HLA-G isoforms, four membrane bound, and other three soluble isoforms that can suffer different posttranslational modifications or even complex formations. In addition, HLA-G has been described included in exosomes. In this review we will focus on HLA-G biochemistry with special emphasis to the mechanisms that regulate its expression and how the protein modifications affect the quantification in biological fluids.





Author: Estibaliz Alegre, Roberta Rizzo, Daria Bortolotti, Sara Fernandez-Landázuri, Enrico Fainardi, and Alvaro González

Source: https://www.hindawi.com/



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