Synthesis and Biological Evaluation of Novel Piperazine Containing Hydrazone DerivativesReport as inadecuate




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Journal of Chemistry - Volume 2016 2016, Article ID 5878410, 7 pages -

Research Article

Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Anadolu University, 26470 Eskişehir, Turkey

Faculty of Pharmacy, Doping and Narcotic Compounds Analysis Laboratory, Anadolu University, 26470 Eskişehir, Turkey

Faculty of Pharmacy, Department of Biochemistry, Anadolu University, 26470 Eskişehir, Turkey

Received 1 March 2016; Revised 22 June 2016; Accepted 17 July 2016

Academic Editor: Patricia Valentao

Copyright © 2016 Betül Kaya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Some hydrazone derivatives were synthesized and their potential anticholinesterase activities were examined. A series of eleven new compounds of N′-2,4-disubstitutedbenzylidene-2-4-4-nitrophenylpiperazin-1-ylacetohydrazide derivatives were obtained via reaction of 2-4-4-nitrophenylpiperazin-1-ylacetohydrazide with aromatic aldehydes. The chemical structures of the compounds were enlightened by FT-IR,

H-NMR,

C-NMR, and HRMS ESI spectral data. The inhibition potency of the compounds 3a–k against AChE and BuChE was measured and evaluated using a modification of Ellman’s spectrophotometric method. Among the tested compounds, compound 3c was assigned to be the most active derivative. Galantamine was used as a standard drug.





Author: Betül Kaya, Yusuf Özkay, Halide Edip Temel, and Zafer Asım Kaplancıklı

Source: https://www.hindawi.com/



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