Serum Antioxidative Enzymes Levels and Oxidative Stress Products in Age-Related Cataract PatientsReport as inadecuate




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Oxidative Medicine and Cellular LongevityVolume 2013 2013, Article ID 587826, 7 pages

Clinical Study

Clinical Labororatory, The First Affiliated Hospital of Harbin Medical University, Harbin 150081, China

Department of Ophtalmology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150081, China

Public Health School, Mudanjiang Medical College, Mudanjiang 157011, China

Department of Ophtalmology, Eye Hospital of Heilongjiang Province and the First Affiliated Hospital of Harbin Medical University, Harbin 150081, China

Department of Nutrition and Food Hygiene, Public Health School of Harbin Medical University, Harbin 150081, China

Received 14 December 2012; Revised 29 April 2013; Accepted 13 May 2013

Academic Editor: Peter Shaw

Copyright © 2013 Dong Chang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Purpose. To investigate the activity of antioxidative enzymes and the products of oxidative stress in patients with age-related cataracts and compare the findings with those in healthy control subjects. Method. Sixty patients with age-related cataract and sixty healthy controls of matched age and gender were included in this study. Serum samples were obtained to detect the antioxidative enzymes of superoxide dismutase SOD, catalase CAT, and glutathione peroxidase GSH-Px, and oxidation degradation products of malondialdehyde MDA, 4-hydroxynonenal 4-HNE, conjugated diene CD, advanced oxidation protein products AOPP, protein carbonyl PC, and 8-hydroxydeoxyguanosine 8-OHdG. Results. Serum SOD, GSH-Px, and CAT activities in cataract group were significantly decreased as compared to the control subjects . The levels of MDA, 4-HNE, and CD in cataract patients were significantly higher than those in the control subjects , . Cataract patients had higher levels of 8-OHdG, AOPP, and PC with respect to the comparative group of normal subjects . And there was no statistical significance in concentration of antioxidative enzymes and oxidative stress products in patients with different subtype cataract. Conclusions. Oxidative stress is an important risk factor in the development of age-related cataract, and augmentation of the antioxidant defence systems may be of benefit to prevent or delay cataractogenesis.





Author: Dong Chang, Xuefei Zhang, Shengzhong Rong, Qian Sha, Peipei Liu, Tao Han, and Hongzhi Pan

Source: https://www.hindawi.com/



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