Sequential Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Intermediate or High-Risk Acute Myeloid Leukemia in Complete Remission: a Study From the ALWP of the EBMTReport as inadecuate




Sequential Intensified Conditioning Regimen Allogeneic Hematopoietic Stem Cell Transplantation in Adult Patients with Intermediate or High-Risk Acute Myeloid Leukemia in Complete Remission: a Study From the ALWP of the EBMT - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 Service d-hématologie clinique et de thérapie cellulaire CHU Saint-Antoine 2 CR Saint-Antoine - Centre de Recherche Saint-Antoine 3 German diagnostic clinic Wiesbaden 4 University of Saarland 5 MHH - Hannover Medical School Hannover 6 University Hospital of the Ludwig-Maximilians University 7 CHU Lyon 8 University Hospital Eppendorf 9 Augsburg Hospital 10 IUCT Oncopole - Institut Universitaire du Cancer de Toulouse - Oncopole 11 University of Cologne 12 Vanderbilt University Nashville 13 CEREST-TC CHU Saint-Antoine 14 EBMT - Centre International des greffes CHU Saint-Antoine

Abstract : Post-transplant relapse is the leading cause of treatment failure in acute myeloid leukemia AML patients after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation allo-HSCT. In order to improve their outcome, we evaluated the outcome of a sequential intermediate intensity conditioning regimen combining fludarabine, cytosine arabinoside, amsacrine, cyclophosphamide and either total body irradiation or busulfan FLAMSA in patients with intermediate or high risk AML in first or second complete remission CR. A total of 265 patients median age 55 years; range, 19-76 years with AML who underwent allo-HSCT using a FLAMSA regimen were included. At the time of transplant, 216 81.5% were in CR1 and 49 18.5% in CR2.

Keywords : Acute myeloid leukemia complete remission allogeneic hematopoietic-stem-cell transplantation sequential conditioning regimen intermediate intensity conditioning regimen





Author: Florent Malard - Myriam Labopin - Gernot Stuhler - Jörg Bittenbring - Arnold Ganser - Johanna Tischer - Mauricette Michallet - N

Source: https://hal.archives-ouvertes.fr/



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