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BioMed Research International - Volume 2016 2016, Article ID 2428915, 8 pages -

Review Article

Institute of Orthopaedics, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopaedics, Key Laboratory of Musculoskeletal Trauma and War Injuries, 28 Fuxing Road, Haidian District, Beijing 100853, China

Shanxi Medical University, No. 56 XinJiannan Road, YingZe District, Taiyuan 030001, China

Minimal Invasive Spine Surgery Center, Spine Division of Orthopaedic Department, Chinese PLA General Hospital, 28 Fuxing Road, Haidian District, Beijing 100853, China

Received 18 July 2016; Revised 9 November 2016; Accepted 13 November 2016

Academic Editor: Magali Cucchiarini

Copyright © 2016 Tianyang Gao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Osteoarthritis OA is a type of chronic joint disease that is characterized by the degeneration and loss of articular cartilage and hyperplasia of the synovium and subchondral bone. There is reasonable knowledge about articular cartilage physiology, biochemistry, and chondrocyte metabolism. However, the etiology and pathogenesis of OA remain unclear and need urgent clarification to guide the early diagnosis and treatment of OA. Extracellular vesicles EVs are small membrane-linking particles that are released from cells. In recent decades, several special biological properties have been found in EV, especially in terms of cartilage. Autophagy plays a critical role in the regulation of cellular homeostasis. Likewise, more and more research has gradually focused on the effect of autophagy on chondrocyte proliferation and function in OA. The synthesis and release of EV are closely associated with autophagy. At the same time, both EV and autophagy play a role in OA development. Based on the mechanism of EV and autophagy in OA development, EV may be beneficial in the early diagnosis of OA; on the other hand, the combination of EV and autophagy-related regulatory drugs may provide insight into possible OA therapeutic strategies.





Author: Tianyang Gao, Weimin Guo, Mingxue Chen, Jingxiang Huang, Zhiguo Yuan, Yu Zhang, Mingjie Wang, Penghao Li, Jiang Peng, Aiy

Source: https://www.hindawi.com/



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