QSAR Studies of 6-Amino Uracil Base Analogues: A Thymidine Phosphorylase Inhibitor in Cancer TherapyReport as inadecuate




QSAR Studies of 6-Amino Uracil Base Analogues: A Thymidine Phosphorylase Inhibitor in Cancer Therapy - Download this document for free, or read online. Document in PDF available to download.

E-Journal of Chemistry - Volume 5 2008, Issue 1, Pages 185-186



Rajiv Gandhi Institute of Pharmacy, Satna M.P.-485001., India

RKDF, College of Pharmacy, Bhopal MP-462021, India

School of Pharmaceutical Sciences, UTD, RGPV, Gandhi Nagar, Bhopal MP- 462036, India

Department of Pharmaceutical Sciences, BIT Mesra, Ranchi Jharkhand, India

Received 24 November 2006; Revised 10 January 2007; Accepted 20 February 2007

Copyright © 2008 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A novel series of 6-amino uracil base analogue were synthesized. QSAR study was used to relate the selective nonsubstrate inhibitory activity of 6-amino uracil base analogue with various physicochemical descriptors. Stepwise multiple regression analysis was performed to find out the correlation between various physicochemical descriptors and biological activity of the compounds by using Openstat 2 version 6.5.1 and valstat statistical software. Out of the several equations developed, the best equation having the highest significance was selected for further study. The equation is able to explain 60% of total variance and are more than 95% significant as revealed by the F value.





Author: Surya Prakash B. N. Gupta, Neeraj Upmanyu, N. S. Hari Narayana Moorthy, and S. Bhattacharya

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents