Chemical diversity of calcifications in thyroid and hypothetical link to diseaseReport as inadecuate

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* Corresponding author 1 Service de Chirurgie digestive, endocrinienne et générale CHU Limoges 2 LPS - Laboratoire de Physique des Solides 3 SMiLES - Spectroscopie, Modélisation, Interfaces pour L-Environnement et la Santé LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris 4 Department of Clinical Pathology 5 Service d-Explorations fonctionnelles multidisciplinaires CHU Tenon 6 Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation

Abstract : Even though calcifications in thyroid nodules constitute a common finding in imaging and histopathology, and also may occur in both benign and malignant thyroid disease, their clinical importance remains unclear. A way to establish a possible relationship between their presence and the associated pathology may be given through a precise description of their chemical composition. In order to attain this goal, last generation Field Effect Scanning Electron Microscopy FE-SEM and classical Fourier Transform Infra Red FT-IR experiments have been performed on thyroid calcifications. Calcifications corresponding to different pathologies have been considered, including Graves- disease, papillary carcinoma or multinodular goiter. The complete set of experiments shows for the first time a chemical diversity of pathological calcifications but no correlation between the chemical composition of the pathological calcifications and the disease.

Keywords : Fourier transform infrared spectroscopy Field Effect Scanning Electron Microscopy Ca Oxalate Ca Phosphate apatites Thyroid Pathological calcifications

Author: Muriel Mathonnet - Arnaud Dessombz - Dominique Bazin - Raphael Weil - Frédéric Triponez - Marc Pusztaszeri - Michel Daudon -



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