A new mathematical model for optimizing the combination between antiangiogenic and cytotoxic drugs in oncologyReport as inadecuate




A new mathematical model for optimizing the combination between antiangiogenic and cytotoxic drugs in oncology - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 LATP - Laboratoire d-Analyse, Topologie, Probabilités 2 CRO2 - Centre de Recherches en Oncologie biologique et Oncopharmacologie

Abstract : We present in this paper a new mathematical model designed to optimize and to rationalize the association between cytotoxic and antiangiogenic drugs in the treatment of a primary tumor. This model takes into account the non-linear interlinkings between both drugs. In particular, this original model integrates the influence of the vasculature state on the delivery of the drugs to the tumor. In the future, this model could be used in clinical oncology to optimize antiangiogenic-based combinational regimen so as to ensure a maximum efficacy.

Keywords : Cancer modelling therapy modelling





Author: Sébastien Benzekry - Guillemette Chapuisat - Joseph Ciccolini - Alice Erlinger - Florence Hubert -

Source: https://hal.archives-ouvertes.fr/



DOWNLOAD PDF




Related documents