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Case Reports in Dermatological MedicineVolume 2014 2014, Article ID 840845, 4 pages

Case ReportDepartment of Dermatology, Davis Health System, University of California, 3301 C Street, Suite 1400, Sacramento, CA 95816, USA

Received 3 December 2013; Accepted 24 December 2013; Published 6 February 2014

Academic Editors: I. D. Bassukas, I. Kurokawa, J.-H. Lee, and J. Y. Lee

Copyright © 2014 Elizabeth A. Brezinski et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Importance. Cutaneous and systemic plasmacytosis are rare conditions of unknown etiology with characteristic red-brown skin lesions and a mature polyclonal plasma cell infiltrate within the dermis. Perineural plasma cell infiltrates may be a histologic clue to the diagnosis of cutaneous plasmacytosis. Observations. Our patient had a five-year history of persistent reddish-brown plaques on the neck and trunk without systemic symptoms. Histologic examination showed dermal perivascular and perineural plasma cells with excess lambda light chain expression. Due to decreased quality of life caused by his skin lesions, he was placed on a chemotherapeutic regimen with bortezomib. Conclusions and Relevance. The patient was diagnosed with cutaneous plasmacytosis based on classic histopathology results with a recently characterized pattern of perineural involvement. Bortezomib therapy was initiated to manage his skin eruption, which has not been previously described as a treatment for this chronic condition.





Author: Elizabeth A. Brezinski, Maxwell A. Fung, and Nasim Fazel

Source: https://www.hindawi.com/



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