Plasma proprotein convertase subtilisin kexin type 9 is a heritable trait of familial combined hyperlipidemiaReport as inadecuate




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* Corresponding author 1 Maastricht University Medical Center

Abstract : Objective: To study the relation between circulating proprotein convertase subtilisin kexin type 9 PCSK9 and familial combined hyperlipidemia FCHL and - when positive - to determine the strength of its heritability. Methods: Plasma PCSK9 levels were measured in FCHL patients n=45, normolipidemic relatives n=139 and their spouses n=72. In addition, eleven FCHL patients were treated with atorvastatin to study the response in PCSK9 levels. Results: PCSK9 levels were higher in FCHL patients versus normolipidemic relatives and spouses: 96.1 versus 78.7 and 82.0 ng-mL, p=0.004 and p=0.002, respectively. PCSK9 was significantly associated with both triglycerides and apolipoprotein B levels p



Author: Martijn C.G.J. Brouwers - Marleen Mj Van Greevenbroek Jason Troutt Angela Bonner Freeman Ake Lu Nicolaas C Schaper Robert John Ko

Source: https://hal.archives-ouvertes.fr/



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