Exaggerated natriuresis during clamping of systemic NO supply in normal manReport as inadecuate




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* Corresponding author 1 Dept. of Nuclear Medicine

Abstract : Nitric oxide NO may be involved in fluid homeostasis. We hypothesized that increases in NO synthesis contribute to acute, saline-induced natriuresis which, therefore, should be blunted when NO availability is stabilized. Young men were studied during simultaneous infusions of Nω-nitro-L-arginine methyl ester L-NAME, 750 µg*kg body weight-1 bolus and 8.3 µg*kg-1*min-1 and sodium nitroprusside, the latter at a rate preventing the L-NAME from increasing total peripheral resistance -NO-clamping-. Slow volume expansion saline, 20 µmol NaCl*kg-1*min-1 for 3 h was performed with and without concomitant NO-clamping. NO-clamping per se decreased renal plasma flow RPF, P ~0.02 and tended to decrease arterial blood pressure MABP. Volume expansion markedly decreased the plasma levels of renin, angiotensin II AngII, and aldosterone all P



Author: Jane Angel Simonsen - Mona Sommer Rasmussen Werner Vach Poul Flemming Høilund-Carlsen Peter Bie

Source: https://hal.archives-ouvertes.fr/



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