Cisplatin and Short-Term 5-Fluorouracil Infusion for Paraneoplastic Microangiopathic Hemolytic Anemia in Gastric Cancer: A Case Report and Review of the LiteratureReport as inadecuate




Cisplatin and Short-Term 5-Fluorouracil Infusion for Paraneoplastic Microangiopathic Hemolytic Anemia in Gastric Cancer: A Case Report and Review of the Literature - Download this document for free, or read online. Document in PDF available to download.

Case Reports in Oncological MedicineVolume 2013 2013, Article ID 594787, 8 pages

Case Report

Department of Medical Oncology, Western University, 790 Commissioners Road East, London, ON, Canada N6A 4L6

Department of Medicine, Division of Hematology, Western University, 800 Commissioners Road E E6-216, London, ON, Canada N6A 5W9

Department of Oncology, Western University, 800 Commissioners Road E E6-216, London, ON, Canada N6A 5W9

Department of Epidemiology and Biostatistics, Western University, 800 Commissioners Road E E6-216, London, ON, Canada N6A 5W9

Medical Oncology, King Abdulaziz Medical City, Princess Noorah Oncology Center, Jeddah, Saudi Arabia

Received 22 October 2013; Accepted 20 November 2013

Academic Editors: L. Beex and S. Ohno

Copyright © 2013 M. S. Sanatani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Microangiopathic hemolytic anemia is a rare paraneoplastic syndrome accompanying adenocarcinoma of the stomach. We report on a patient presenting with anemia due to a combination of severe hemolysis and tumour bleeding, where the combination of cisplatin and 5-fluorouracil in a short course infusional regimen led to a complete response of the hematologic abnormalities in the first line setting. Relapse was successfully treated with second line docetaxel; however the response was relatively short-lived. Overall survival was 16 months from diagnosis, which compares favourably to the survival of other reported cases. The chemotherapy regimens used in previously reported similar cases are reviewed. We suggest that a regimen based on bolus 5-fluorouracil, possibly with a platinum, should be investigated as a possible regimen of choice.





Author: M. S. Sanatani, A. Lazo-Langner, and I. M. Al-Rasheedy

Source: https://www.hindawi.com/



DOWNLOAD PDF




Related documents