Microwave Assisted Heterocyclization: A Rapid and Efficient Synthesis and Antibacterial Activity of Novel ThiazolidinonesReport as inadecuate




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E-Journal of Chemistry - Volume 1 2004, Issue 5, Pages 263-266

Department of Chemistry, South Gujarat University, Surat-395 007, India

Received 16 September 2004; Accepted 10 October 2004

Copyright © 2004 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

As a target to synthesize various Thiazolidinone derivatives, 2-Amino-4-coumarin-3-yl-thiazole has been prepared by the reactions of 3-Bromo acetyl coumarin with thiourea. 3-Bromo acetyl coumarin was prepared from 3-Acetyl coumarin. The resulting compound 2-amino-4-coumarin-3-yl- thiazole was treated with different Aldehydes to give the intermediate Schiff base, which on further reaction with Thioglycolic acid and Thiolactic acid to give titled compound Thiazolidinone. The structures of the compounds have been confirmed by elemental analysis and spectral analysis. The antibacterial activity of the compounds has also been screened against Staphylococcus aureus and Escherichia coil.





Author: B. D. Naik and K. R. Desai

Source: https://www.hindawi.com/



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