Comments to the Editor. Reply to the Comment by V.P. Shkilev on Anomalous versus slowed-down Brownian diffusion in the ligand-binding equilibriumReport as inadecuate




Comments to the Editor. Reply to the Comment by V.P. Shkilev on Anomalous versus slowed-down Brownian diffusion in the ligand-binding equilibrium - Download this document for free, or read online. Document in PDF available to download.

* Corresponding author 1 BEAGLE - Artificial Evolution and Computational Biology LIRIS - Laboratoire d-InfoRmatique en Image et Systèmes d-information, Inria Grenoble - Rhône-Alpes, LBBE - Laboratoire de Biométrie et Biologie Evolutive, CarMeN - Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition 2 CarMeN - Laboratoire de recherche en cardiovasculaire, métabolisme, diabétologie et nutrition 3 LIRIS - Laboratoire d-InfoRmatique en Image et Systèmes d-information 4 Inria Grenoble - Rhône-Alpes

Abstract : In his comment in this issue of the Biophysical Journal, V.P. Shkilev 1 disagrees with some of the findings of our article on the influence of diffusion on the ligand-binding equilibrium 2. V.P. Shkilev makes two main claims in his comment: i when diffusion is uniformly Brownian with a space-independent diffusion coefficient -the equilibrium fraction of bound receptors

. should depend on the dif- fusion coefficient- and ii when molecules undergo tran- sient subdiffusion due to a Continuous-Time Random Walk CTRW, the equilibrium fraction of bound receptors can only be equal or larger but not smaller than the value ex- pected for uniform Brownian motion with comparable dif- fusion coefficient. While the former is a frequent miscon- ception related to the ligand-binding equilibrium, the lat- ter relates to an important issue in the field of anomalous subdiffusion-reaction couplings.





Author: Hédi Soula - Bertrand Caré - Guillaume Beslon - Hugues Berry -

Source: https://hal.archives-ouvertes.fr/



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