Association of Postbreakfast Triglyceride and Visit-to-Visit Annual Variation of Fasting Plasma Glucose with Progression of Diabetic Nephropathy in Patients with Type 2 DiabetesReport as inadecuate




Association of Postbreakfast Triglyceride and Visit-to-Visit Annual Variation of Fasting Plasma Glucose with Progression of Diabetic Nephropathy in Patients with Type 2 Diabetes - Download this document for free, or read online. Document in PDF available to download.

Journal of Diabetes Research - Volume 2016 2016, Article ID 4351376, 5 pages -

Research Article

Research Institute for Nutrition Sciences, Mukogawa Women’s University, Nishinomiya, Hyogo, Japan

Department of Nutritional Sciences for Well-Being, Faculty of Health Sciences for Welfare, Kansai University of Welfare Sciences, Kashiwara, Japan

Department of Food Sciences and Nutrition, School of Human Environmental Sciences, Mukogawa Women’s University, 6-46 Ikebiraki-Cho, Nishinomiya, Hyogo 663-8558, Japan

Diabetes Division, Sadamitsu Hospital, Kakogawa, Hyogo 675-0005, Japan

Received 2 July 2016; Accepted 2 November 2016

Academic Editor: Patrizio Tatti

Copyright © 2016 Kaori Kitaoka et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Urinary albumin-creatinine ratio ACR was measured at baseline and after a median follow-up of 6.0 years in 161 patients with type 2 diabetes. Intrapersonal means and SD of HbA1c, systolic BP, fasting, and postmeal plasma glucose FPG and PMPG, resp. and serum triglycerides FTG and PMTG, resp. were calculated in each patient during the first 12 months after enrollment. Associations of these variables with nephropathy progression 15 patients with progression of albuminuric stages and 5 with ACR doubling within the microalbuminuric range were determined by multivariate logistic regression analysis providing odds ratio with 95% confidential interval. Patients with nephropathy progression, compared with those without nephropathy progression, had higher HbA1c . They also had higher means and SD of FPG both , FTG both , and PMTG . Multivariate logistic regression analysis demonstrated that SD-FPG 1.036, 1.001–1.073, and PMTG 1.013, 1.008–1.040, were significant predictors of progression of nephropathy even after adjustment for mean FPG and SD-FTG, age, sex, BMI, waist circumference, diabetes duration and therapy, means and SDs of HbA1c, PPG, FTG and systolic BP, baseline ACR, smoking status, and uses of antihypertensive and lipid-lowering medications. Consistency of glycemic control and management of postmeal TG may be important to prevent nephropathy progression in type 2 diabetic patients.





Author: Kaori Kitaoka, Akiko Takenouchi, Ayaka Tsuboi, Keisuke Fukuo, and Tsutomu Kazumi

Source: https://www.hindawi.com/



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