Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based CohortReport as inadecuate




Ductal Breast Carcinoma In Situ: Mammographic Features and Its Relation to Prognosis and Tumour Biology in a Population Based Cohort - Download this document for free, or read online. Document in PDF available to download.

International Journal of Breast Cancer - Volume 2017 2017, Article ID 4351319, 9 pages - https:-doi.org-10.1155-2017-4351319

Research Article

Department of Surgical Sciences, Uppsala University, Uppsala Academic Hospital, Uppsala, Sweden

Department of Pathology, Örebro University, Örebro, Sweden

Department of Pathology, Falun Central Hospital, Falun, Sweden

Department of Oncology, Helsinki University Central Hospital, Helsinki, Finland

Department of Radiology, Oncology and Radiation Science, Uppsala University, Uppsala, Sweden

Department of Surgery, Örebro University, Örebro, Sweden

Correspondence should be addressed to Fredrik Wärnberg

Received 4 October 2016; Revised 30 December 2016; Accepted 17 January 2017; Published 14 February 2017

Academic Editor: Debra A. Tonetti

Copyright © 2017 Wenjing Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Casting-type calcifications and a histopathological picture with cancer-filled duct-like structures have been presented as breast cancer with neoductgenesis. We correlated mammographic features and histopathological neoductgenesis with prognosis in a DCIS cohort with long follow-up. Mammographic features were classified into seven groups according to Tabár. Histopathological neoductgenesis was defined by concentration of ducts, lymphocyte infiltration, and periductal fibrosis. Endpoints were ipsilateral IBE in situ and invasive events. Casting-type calcifications and neoductgenesis were both related to high nuclear grade, ER- and PR-negativity, and HER2 overexpression but not to each other. Casting-type calcifications and neoductgenesis were both related to a nonsignificant lower risk of invasive IBE, HR 0.38 0.13–1.08 and 0.82 0.29–2.27, respectively, and the HR of an in situ IBE was 0.90 0.41–1.95 and 1.60 0.75–3.39, respectively. Casting-type calcifications could not be related to a worse prognosis in DCIS. We cannot explain why a more aggressive phenotype of DCIS did not correspond to a worse prognosis. Further studies on how the progression from in situ to invasive carcinoma is driven are needed.





Author: Wenjing Zhou, Thomas Sollie, Tibor Tot, Carl Blomqvist, Shahin Abdsaleh, Göran Liljegren, and Fredrik Wärnberg

Source: https://www.hindawi.com/



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