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Infectious Diseases in Obstetrics and GynecologyVolume 2011 2011, Article ID 754060, 5 pages

Review ArticleDepartment of Pediatrics, University of Pittsburgh School of Medicine, Rangos Research Center, Room 9123, 4401 Penn Avenue, Pittsburgh, PA 15224, USA

Received 15 July 2011; Accepted 29 August 2011

Academic Editor: Richard L. Sweet

Copyright © 2011 Jean M. Chavez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Chlamydia trachomatis control efforts that enhance detection and treatment of infected women may paradoxically increase susceptibility of the population to infection. Conversely, these surveillance programs lower incidences of adverse sequelae elicited by genital tract infection e.g., pelvic inflammatory disease and ectopic pregnancy, suggesting enhanced identification and eradication of C. trachomatis simultaneously reduces pathogen-induced upper genital tract damage and abrogates formation of protective immune responses. In this paper, we detail findings from C. trachomatis infection control programs that increase our understanding of chlamydial immunoepidemiology and discuss their implications for prophylactic vaccine design.





Author: Jean M. Chavez, Rodolfo D. Vicetti Miguel, and Thomas L. Cherpes

Source: https://www.hindawi.com/



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