Human Induced Pluripotent Stem Cells from Basic Research to Potential Clinical Applications in CancerReport as inadecuate




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BioMed Research InternationalVolume 2013 2013, Article ID 430290, 11 pages

Review Article

National Cancer Institute INCA, Bone Marrow Transplantation Center CEMO, Laboratory Division, 20230-130 Rio de Janeiro, RJ, Brazil

Mathematics and Statistics Institute, Federal Fluminense University UFF, 24020-140 Niterói, RJ, Brazil

State University of Rio de Janeiro UERJ, Roberto Alcântara Gomes Biology Institute, Department of Biophysics and Biometrics, 20551-030 Rio de Janeiro, RJ, Brazil

Received 12 August 2013; Accepted 15 September 2013

Academic Editor: Ken-ichi Isobe

Copyright © 2013 Teresa de Souza Fernandez et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The human induced pluripotent stem cells hiPSCs are derived from a direct reprogramming of human somatic cells to a pluripotent stage through ectopic expression of specific transcription factors. These cells have two important properties, which are the self-renewal capacity and the ability to differentiate into any cell type of the human body. So, the discovery of hiPSCs opens new opportunities in biomedical sciences, since these cells may be useful for understanding the mechanisms of diseases in the production of new diseases models, in drug development-drug toxicity tests, gene therapies, and cell replacement therapies. However, the hiPSCs technology has limitations including the potential for the development of genetic and epigenetic abnormalities leading to tumorigenicity. Nowadays, basic research in the hiPSCs field has made progress in the application of new strategies with the aim to enable an efficient production of high-quality of hiPSCs for safety and efficacy, necessary to the future application for clinical practice. In this review, we show the recent advances in hiPSCs’ basic research and some potential clinical applications focusing on cancer. We also present the importance of the use of statistical methods to evaluate the possible validation for the hiPSCs for future therapeutic use toward personalized cell therapies.





Author: Teresa de Souza Fernandez, Cecilia de Souza Fernandez, and André Luiz Mencalha

Source: https://www.hindawi.com/



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