Proteinuria, 99mTc-DTPA Scintigraphy, Creatinine-, Cystatin- and Combined-Based Equations in the Assessment of Chronic Kidney DiseaseReport as inadecuate




Proteinuria, 99mTc-DTPA Scintigraphy, Creatinine-, Cystatin- and Combined-Based Equations in the Assessment of Chronic Kidney Disease - Download this document for free, or read online. Document in PDF available to download.

ISRN Nephrology - Volume 2014 2014, Article ID 430247, 16 pages -

Research Article

Servicios de Nefrología, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina

Laboratorio Central, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina

Servicios de Medicina Nuclear, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina

Servicios de Clínica Médica, Hospital Británico de Buenos Aires, Perdriel 74, 1280 Buenos Aires, Argentina

Received 4 September 2013; Accepted 7 November 2013; Published 11 February 2014

Academic Editors: A. M. Castelao, E. F. Elsayed, and C. Escobar

Copyright © 2014 Hernán Trimarchi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Precise estimation of the glomerular filtration rate GFR and the identification of markers of progression are important. We compared creatinine, cystatin, and combined CKD-EPI equations with scintigraphy to measure GFR and proteinuria as markers of progression. Methods. Cross-sectional, observational study including 300 subjects. CKD was classified by scintigraphy. Determinations. Creatinine, 24-hour creatinine clearance, cystatin, Hoek formula, and creatinine, cystatin, and combined CKD-EPI equations. Results. In the global assessment, creatinine CKD-EPI and combined CKD-EPI equations yielded the highest correlations with : ρ = 0.839, and ρ = 0.831, . Intergroup analysis versus : control G, creatinine clearance ρ = 0.414, P = 0.013; G3, combined CKD-EPI ρ = 0.5317, ; G4, Hoek ρ = 0.618, , combined CKD-EPI ρ = 0.4638, ; and G5, creatinine clearance ρ = 0.5414, , combined CKD-EPI ρ = 0.5288, . In the global assessment, proteinuria displayed the highest significant correlations with cystatin ρ = 0.5433, and cystatin-based equations Hoek: , . When GFR < 60 mL-min: in stage 3, proteinuria-cystatin ρ = 0.4341, ; proteinuria-Hoek ρ = −0.4105, ; in stage 4, proteinuria-cystatin ρ = 0.4877, ; proteinuria-Hoek ρ = −0.4877, P = 0.0026. Conclusions. At every stage of GFR < 60 mL-min, cystatin-based equations displayed better correlations with . Proteinuria and cystatin-based equations showed strong associations and high degrees of correlation.





Author: Hernán Trimarchi, Alexis Muryan, Agostina Toscano, Diana Martino, Mariano Forrester, Vanesa Pomeranz, Fernando Lombi, Pabl

Source: https://www.hindawi.com/



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