Dupuytrens disease: personal factors and occupational exposure.Report as inadecuate

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* Corresponding author 1 DRTEFP 2 Laboratoire d-ergonomie et de santé au travail 3 Santé publique et épidémiologie des déterminants professionnels et sociaux de la santé 4 Unité de pathologie professionnelle

Abstract : BACKGROUND: The etiology of Dupuytren-s disease is unknown, and the role of occupational exposure is still debated. Our objective was to study the association between occupational exposures, personal risk factors and Dupuytren-s disease. METHODS: In this cross-sectional survey, nine occupational physicians performed clinical examinations, focused on Dupuytren-s disease, of 2,406 French male civil servants employed at the Equipment Ministry in 1998 and interviewed them about medical history, leisure manual exposure and occupational biomechanical exposure to vibrations and manual work. A cumulative occupational exposure score was defined, with three levels of exposure. RESULTS: Dupuytren-s disease was diagnosed in 212 men 8.8%. The occupational exposure score was significantly higher in this group of cases than in the rest of the sample 377 SD280 vs. 223 SD250, respectively; P < 0.0001. Occupational exposure was associated with Dupuytren-s disease adjusted Odds Ratio = 2.20 1.39-3.45 for the intermediate and 3.10 1.99-4.84 for the high exposure groups, with adjustment for age, leisure physical activities, alcohol consumption > or =5 servings per day, history of diabetes, epilepsy, hand trauma, and familial history of Dupuytren-s disease. CONCLUSION: Manual work exposure was associated with Dupuytren-s disease after adjustment for personal risk factors. Longitudinal studies are needed to confirm these results.

Author: Gérard Lucas - Anne Brichet - Yves Roquelaure - Annette Leclerc - Alexis Descatha -

Source: https://hal.archives-ouvertes.fr/


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