Extracorporeal shock wave therapy does not improve hypertensive nephropathyReport as inadecuate




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1 Des Maladies Rénales Rares aux Maladies Fréquentes, Remodelage et Réparation 2 Service de Néphrologie et Dialyses CHU Tenon

Abstract : Low-energy extracorporeal shock wave therapy SWT has been shown to improve myocardial dysfunction, hind limb ischemia, erectile function, and to facilitate cell therapy and healing process. These therapeutic effects were mainly due to promoting angiogenesis. Since chronic kidney diseases are characterized by renal fibrosis and capillaries rarefaction, they may benefit from a proangiogenic treatment. The objective of our study was to determine whether SWT could ameliorate renal repair and favor angiogenesis in L-NAME-induced hypertensive nephropathy in rats. SWT was started when proteinuria exceeded 1 g-mmol of creatinine and 1 week after L-NAME removal. SWT consisted of implying 0.09 mJ-mm 2 400 shots, 3 times per week. After 4 weeks of SWT, blood pressure, renal function and urinary protein excretion did not differ between treated LN + SWT and untreated rats LN. Histo-logical lesions including glomerulosclerosis and arteriolosclerosis scores, tubular dilatation and interstitial fibrosis were similar in both groups. In addition, peritubular capillaries and eNOS, VEGF, VEGF-R, SDF-1 gene expressions did not increase in SWT-treated compared to untreated animals. No procedural complications or adverse effects were observed in control C + SWT and hypertensive rats LN + SWT. These results suggest that extracorporeal kidney shock wave therapy does not induce angiogenesis and does not improve renal function and structure, at least in the model of hypertensive nephropa-thy although the treatment is well tolerated.

Keywords : chronic kidney disease renal repair angiogenesis Renal fibrosis





Author: Jonathan Caron - Pierre‐antoine Michel - Jean‐claude Dussaule - Christos Chatziantoniou - Pierre Ronco - Jean‐jacques Boffa

Source: https://hal.archives-ouvertes.fr/



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