What Is the Most Realistic Single-Compartment Model of Spike InitiationReport as inadecuate




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* Corresponding author 1 Institut de la Vision 2 Institut d-études de la cognition

Abstract : A large variety of neuron models are used in theoretical and computational neuroscience, and among these, single-compartment models are a popular kind. These models do not explicitly include the dendrites or the axon, and range from the Hodgkin-Huxley HH model to various flavors of integrate-and-fire IF models. The main classes of models differ in the way spikes are initiated. Which one is the most realistic? Starting with some general episte-mological considerations, I show that the notion of realism comes in two dimensions: empirical content the sort of predictions that a model can produce and empirical accuracy whether these predictions are correct. I then examine the realism of the main classes of single-compartment models along these two dimensions, in light of recent experimental evidence.





Author: Romain Brette -

Source: https://hal.archives-ouvertes.fr/



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